1International Dark-Sky Association

The International Dark-Sky Association is an organization dedicated to fighting light pollution and preserving the night sky in areas around the planet called dark sky reserves.
2Think Before You Pink

There is an organization called Think Before You Pink which warns you of other organizations that are profiting from Breast Cancer Awareness.
3Cicada 3301

There is a cryptic organization called Cicada 3301 that posts challenging puzzles and games online, possibly to recruit codebreakers and linguists.
4National Odd Shoe Exchange

There is an organization called the National Odd Shoe Exchange where you can send and receive shoes if your feet are different sizes.
5Wine to Water

There is an organization that utilizes wine tastings to dig wells in Africa. They call themselves Wine to Water.
6Eve Appeal

The Eve Appeal is a UK organization that raises awareness about gynecological cancers. It found that only half of women aged 26- 35 were able to label the vagina accurately.
7B612

There is a non-profit organization called B612 which is dedicated to defending the Earth against asteroids.
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8Knights of Pythias

The first fraternal organization to be chartered by an act of US Congress was the Knights of Pythias, a still-active secret society with the motto "Friendship, Charity, Benevolence." Notable Knights include Franklin D. Roosevelt and Louis Armstrong.
9VETPAW

There is an organization of US military veterans called VETPAW that's helping anti-poaching efforts in African wildlife parks. They train park rangers for free and help them track, identify and arrest poachers using tactics they learned while deployed.
10Phoebus Cartel

The Phoebus Cartel was a secret organization which intentionally shortened the lifespan of light bulbs to force consumers to buy bulbs more often.