In Silence of the Lambs, Hannibal Lecter tells Clarice that he ate a man's liver with fava beans and “a nice Chianti.” All of these foods interfere with MAOI antidepressants, which are used to treat various personality disorders as well. In other words, Hannibal wasn't taking his meds.
In ‘Saw’ (2004), the Jigsaw killer’s identity is revealed early on when blueprints for the infamous reverse bear trap are seen on John Kramer’s hospital desk.
Voldemort makes a living appearance in every Harry Potter film except for the Prisoner of Azkaban, but you can still see him appear inside a portrait in the movie.
In Lord of the Rings, Gollum's pupils are tiny when he is in his "Gollum" persona, but they become much bigger when he switches to "Sméagol."
In The Matrix Reloaded the color of Agent Smith's suit changes from dark green to black, reflecting his 'unplugged' state
In Terminator 2, the only time that the T-1000 and T-800 actually talk to each other, they are both impersonating other people.
In Scarface (1983), Tony Montana sees the phrase "the world is yours" on an airship advertising for Pan American Airlines. Later in the movie, he has a globe with that phrase on it in the entrance hall of his luxury mansion.
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At the beginning of "The Usual Suspects" (1995), Keyser Söze is seen with the things Roger "Verbal" Kint claims before his release at the end of the film.
In The Dark Knight Rises, during the masquerade scene, everyone is wearing a physical mask except Bruce Wayne and Miranda Tate. Wayne (Batman) and Tate (Talia al Ghul) are the masks to their real personas.
In the Goodbye Horses scene in “The Silence of the Lambs”, Buffalo Bill is wearing a woman’s scalp.