Dan Aykroyd had JT Walsh fired from Loose Cannons (1990) after finding out he acted in the John Belushi biopic Wired (1989). The delay in production cost $125,000.
Actor David Herman (Michael Bolton from the movie "Office Space") got himself fired from MADtv by screaming all his lines during the read-through. Apparently, he wanted to leave the show to do other projects, but Fox would not let him out of his contract.
Fitness model Christian Boeving starred in the documentary Bigger, Stronger, Faster* about the use of steroids in America. He said he had a testosterone prescription from his doctor. For this, he was fired by his sponsor MuscleTech, which has a policy against disclosing steroid use publicly.
English journalist Piers Morgan was fired as the editor of a popular British newspaper in 2004 after publishing fake photos of the torture of Iraqi prisoners by British soldiers.
Rick Moranis was fired from the set of The Breakfast Club after he kept playing the janitor as a goofy Russian character.
Suzanne Somers was fired from tv series Three's Company when she asked to be paid equally to costar John Ritter.
Sebastian Bach was fired from Skid Row because he wanted to open for KISS and the band refused. After he was canned he left the band a voicemail saying that nobody is ever too big to open for KISS.
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American actor Gilbert Gottfried was fired from voicing the Aflac duck after he tweeted out a series of jokes about the earthquake disaster of Japan in 2011. Aflac does 75% of its business in Japan.
Bobby Keys, a sax player (and Keith Richards' best friend) was fired from the Rolling Stones 1973 tour after being found in a bathtub filled with Dom Perignon champagne. The cost of the champagne was deducted from his pay and he made no money from the tour.
TV show host Marc Summers went public about his Obsessive Compulsive Disorder, causing him to be fired as host of the Hollywood Squares revival, and is in remission for chronic lymphatic leukemia.