Depression Mechanism Brain Mystery

For decades, the public heard that depression was caused by a simple shortage of serotonin, but large modern reviews have found that evidence does not support that neat chemical-imbalance story. Neuroscientists have been pushing back on that idea for years, arguing that depression is far more complex than one low brain chemical. Antidepressants can still help many patients, but researchers do not have one complete, settled explanation for exactly how these drugs work.

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