Schizophrenia And Bipolar Share Genetics

A 2025 study found that 70% of the genetic signal associated with schizophrenia also appears in bipolar disorder, revealing far more biological overlap than researchers previously recognized. Researchers analyzed DNA from more than 1 million people diagnosed with at least one of 14 psychiatric disorders and 5 million people without those diagnoses. They identified five genomic factors involving 238 genetic variants and placed schizophrenia and bipolar disorder in the same category.

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